| abstract |
NEW MATERIAL:A lower alkanoic acid derivative expressed by formula I (R a 1 is hydroxy, halogen, nitro, amino, 3W8C cycloalkyl aryl or aryloxy which may be substituted by halogen; R 2 is H, halogen or lower alkyl; R 3 is carboxyl or protected carboxyl; Y a is S, O or CH 2 ; A is lower alkylene, however, R a 1 is a group other than halogen when R 2 is H and Y a is S or O) and a pharmaceutically acceptable salt thereof. n EXAMPLE: 2-Oxo-5,6-dichloro-3-benzothiazolineacetic acid. n USE: A preventing agent and remedy for diabetic complication, e.g. diabetic cataract, neuropathy, retinopathy and renopathy. n PROCESS: A compound of formula II or a salt thereof is reacted with a compound of formula III X 1 -A-R 3 (X 1 is acid residue) or a salt thereof. n COPYRIGHT: (C)1981,JPO&Japio |