| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6831b19bfc354357342f7c7da79fc162 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate |
1979-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59dbd497fbf7ffaf191d785de4462fda
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a22f0358da44e900e33959a428ea41d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88832db0e6e878a2c0b95c9b5139dc72 |
| publicationDate |
1981-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S5697266-A |
| titleOfInvention |
Proline derivative and its preparation |
| abstract |
NEW MATERIAL:A proline derivative expressed by formula I (R 1 is lower alkyl) or a pharmacologically acceptable salt thereof. n EXAMPLE: N-[N-Ethyl-N-(N-hydroxycarbamoylmethyl)carbamoyl]-L-proline. n USE: A hypotensive agent having improved inhibitory action on an angiotensin converting enzyme. n PROCESS: A proline benzyl ester is reacted with phosgene to give benzyl ester of an N-chlorocarbonylproline, which is then condensed with a hydroxamic acid derivative of formula II. The resultant proline derivative of formula III is further catalytically reduced to give the compound of formula I. n COPYRIGHT: (C)1981,JPO&Japio |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6797820-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6852752-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0144178-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4804676-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0061684-A1 |
| priorityDate |
1979-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |