http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5679667-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2fb784feb0deee31fdf1cd0665485b8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 |
| filingDate | 1979-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b50adb15bcb69ba3c37be6bfced02292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6092e96e3cbeee49d30a34dc3d7f6d11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ba25aad063142c3d0c6befafe37a773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88fdc2bd6279aecccfb056c95123603e |
| publicationDate | 1981-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5679667-A |
| titleOfInvention | Preparation of erythro 2- 4-benzylpiperidino -1- 4- hydroxyphenyl propanol |
| abstract | PURPOSE: To obtain the titled compound simply and in high yield, by reducing 4'- benzyloxy-2(4-benzylpiperidino)propiophenone in the form of a salt or in the presence of an acidic substance with sodium boron hydride, followed by debenzylation. n CONSTITUTION: 4'-Benxyloxy-2-(4-benzylipiperidino)propiophenone shown by the formula II is reduced with sodium boron hydride in the state of a salt of the compound or in the presence of an acidic substance (e.g., hydrochloric acid, acetic acid, etc.), to give an alcohol derivative shown by the formula II, which is debenzylated to give erythro 2-(4-benzylpiperidiono)-1-(4-hydroxyphenyl)propanol shown by the formula I. The reduction with sodium boron hydride in the state of a salt of the propiophenone shown by the formula III or in the presence of the acidic substance provids the erythro derivatice shown by the formula II in high selectivity. n USE: An improving agent for cerebrovascular stream and remedy for sequela of cerabral infract. n COPYRIGHT: (C)1981,JPO&Japio |
| priorityDate | 1979-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.