http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5663993-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204ea9f0f83d1c51a916e46a41a6a14a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-234 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-236 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 |
| filingDate | 1979-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce03f3e4c316a7c744a4d6552acd3a2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92b5dbdbb2968008aeb158620c8ee760 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc3ff885db1cd16733d1765fcb73eb2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9be2d577a94e670a1a6dd05d220f9d2 |
| publicationDate | 1981-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5663993-A |
| titleOfInvention | Novel preparation of tobramycin |
| abstract | PURPOSE: To prepare the titled compound useful as an antimicrobial agent, etc., economically, in an industrial scale, by reacting a specific 3'-O-sulfonylated kanamycin B protected derivative with a metal halide, reducing the 3'-halo group, and then eliminating the protecting group. n CONSTITUTION: A 3'-O-sulfonylated kanamycin B protectd derivative of formula I (R is hydrocarbon; Y is 1W6C alkylidene, etc. which acts as a bivalent PH-protecting group; Z is arylsulfonyl which acts as amino-protecting group) is made to react with a metal halide of formula MX (M is metal; X is Cl, Br or I) to obtain a 3'-halogenated product of formula II. The objective compound is prepared by reducing the compound of formula II to 3'-deoxykanamycin B protected derivative wherein the 3'-halo group is substituted by hydrogen, and if necessary, eliminating the remaining amino-protecting group and hydroxyl-protecting group from the product by conventional process. n COPYRIGHT: (C)1981,JPO&Japio |
| priorityDate | 1979-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.