| abstract |
NEW MATERIAL:A thiazole derivative shown by the formula I (X is H, halogen, lower alkyl, or trifluoromethyl; R is H, lower alkyl, lower alkenyl, or lower acyl; n is 1 or 2). n EXAMPLE: 4-[4-(4-chlorobenzyloxy)phenyl]-2-methylaminothiazol. n USE: A remedy or preventive for hyperlipemia, pultaceous arterial sclerosis, and malum cordis caused by them of human beings and mammals. n PROCESS: For example, a compound shown by the formula II (Y is halogen) is reacted with a compound shown by the formula III in an amount preferably equimolar with the compound shown by the formula II, more preferably 1W2mol in a solvent, e.g., methanol, etc., to give a compound shown by the formula I. n COPYRIGHT: (C)1981,JPO&Japio |