| abstract |
NEW MATERIAL:Derivatives of acylated indole of formula I [R 1 is lower alkyl or (substituted) phenyl; R 2 is H or lower alkyl; R 3 and R 4 are H, halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, amino, lower alkyl-substituted amino, trifluoromethyl, etc., or R 3 and R 4 together form methylenedioxy or ethylenedioxy; ϕ is aryl or alicyclic group]. n EXAMPLE: 3-Benzoyl-2-methyl-1-(3-oxo-2-butyl) indole. n USE: Preventive agent for cardiac vascular infarction, preventive and treatment agent for post-operative diseases, antiinflamatory agent, fibrinolytic agent etc. It has excellent activity to suppress the coagulation of blood platelets. n PROCESS: A compound of formula I is obtained by the reaction of e.g. a compound of formula II with a compound of formula III (X is halogen) in the presence of a basic compound. n COPYRIGHT: (C)1981,JPO&Japio |