| abstract |
NEW MATERIAL:1,2-Benzisothiazole derivatives of formula I (R 1 , R 2 , R 3 are the same or different H, lower alkyl). n EXAMPLE: 5-Methy-3-vinyl-1,2-benzisothiazole. n USE: A medical preparation having ultromotivity-inhibiting activity, anti-inflammatory analgesic activity or antimicrobial activity. n PREPARATION: For example, a compound of formula II and O-mesitylenesulfonyl hydroxylamine are made to react in a dichloromethane. The sulfylimine derivative formed is isolated or not isolated and treated with caustic soda or potassium carbonate or passed through Amberlite (ion-exchange resin) to give the compound of formula I. n COPYRIGHT: (C)1981,JPO&Japio |