| abstract |
NEW MATERIAL:A codeinone 7,8-oxide shown by the formula I. n USE: A drug having action, e.g., pain-killing, antitussive and sedative action, etc. n PROCESS: For example, codeinone shown by the formula II is reacted with an oxidizing agent, e.g., hydroperoxide, t-butylhydroperoxide, etc. in a solvent, e.g., water, methanol, methylene chloride, etc. in the presence of a base, preferably an alkali carbonate, etc. to give a compound shown by the formula I. n COPYRIGHT: (C)1981,JPO&Japio |