| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd115dec46c157d3739020ebd4d866b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate |
1979-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fe5fbcb7aca66f7ec932c19e0d19b83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b44a39aa2a21570b5e5397489ec0a52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8a070725325c41617038239334faa7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4042cfdca958b0f1dc2defd181b45a01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55a17b916a56ca5e8e3ffd97272912f2 |
| publicationDate |
1981-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S563000-A |
| titleOfInvention |
Water-soluble cholesterol derivative |
| abstract |
NEW MATERIAL:7-Keto and 7-hydroxycholesterol organic dibasic acid half ester (salt) of formula I (R 1 is =0 or -OH; R 2 is 1W5C alkylene or phenylene). n USE: Cellular immunosuppressive agent and antiphlogistic agent having excellent immunosuppressive activity. n PROCESS: A 7-ketocholesterol organic dibasic acid half ester of formula I wherein R 1 is =0, is prepared by reacting 7-ketocholesterol (1mol) with a reactive derivative of the corresponding organic dibasic acid of formula II (e.g. succinic acid) (pref. 1W3mol) in the presence of a tertiary amine such as pyridine. The product can be converted to the 7-hydroxycholesterol organic dibasic acid half ester of formula I wherein R 1 is -OH, by reducing with pref. 1W10mol, based on 1mol of the above product, of a metal hydride complex such as sodium borohydride. n COPYRIGHT: (C)1981,JPO&Japio |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9884067-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S60258198-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2003022866-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012516900-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0140040-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10098896-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9808472-B2 |
| priorityDate |
1979-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |