http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5618959-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2de3beee83d9c19278da409b72c777a8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-277 |
| filingDate | 1979-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bbc7f94e2ef0dabaf788604e8d1e161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a561131e7fb1415790064188deb5a00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59b72f1da74dc80480bf5c440b9dc994 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_934b5507d895ea200465b24625558be5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0234284d647b64d81e625e28878f05ad |
| publicationDate | 1981-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5618959-A |
| titleOfInvention | 4-oxoproline derivative, its preparation, and pharmaceutical composition containing the same |
| abstract | NEW MATERIAL:A 4-oxoproline derivative of formula I (R 1 is H, lower alkanoyl, or benzoyl; R 2 is H or lower alkyl; R is H or lower alkyl), and when R is H, a nontoxic salt of the acid. n EXAMPLE: (2S)-1-[3-Acetylthio-2(RS)-methylpropanoyl]-4-oxoproline. n USE: Hypotensor for oral or nonoral administration, having angiotensinase-inhibiting activity. n PROCESS: A compound of formula I wherein R 1 is lower alkanoyl or benzoyl, i.e. a compound of formula III, is prepared e.g. by reacting a compound of formula II (R 3 is lower alkanoyl or benzoyl) in the presence of an oxidizing agent such as chromic anhydride. A compound of formula I wherein R 1 is H is prepared by hydrolyzing a compound of formula III under basic conditions. n COPYRIGHT: (C)1981,JPO&Japio |
| priorityDate | 1979-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.