| abstract |
NEW MATERIAL:A substituted benzylidene hydrazinophthalazine derivative expressed by formula I [A is substituted aminohydroxypropoxy of formula II (R is H, alkyl or ≤10C aralkyl which may be substituted by up to 2 methoxyl groups), and group A is substituted at the o-, m- or p-position to the phthalazinylhydrazonomethyl group; B is H, Br or metoxyl; however, B is H when A is substituted at the o- or m-position] and a salt thereof. n EXAMPLE: 1- [ 4- ( 3-Iso-propylamino-2-hydroxypropoxy ) benzylidene hydrazino ] phthalazine. n USE: A hypotensive agent having blocking action on the sympathetic β-receptor and vasodilator action. n PROCESS: A compound expressed by formula II (Q is formula IV, etc.) is reacted with a primary amine expressed by the formula R-NH 2 . n COPYRIGHT: (C)1981,JPO&Japio |