http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S56166187-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 1980-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5712564b197ef2590552808284426f1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_084f6a5ff20948cac385ef4ed4f22d56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f6e6874fd18c9beec762383db4a66cd |
| publicationDate | 1981-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S56166187-A |
| titleOfInvention | Indole derivative, its preparation and its use |
| abstract | NEW MATERIAL:3-(4-Indolyloxy)1,2-propyelene carbonate of the formula. n USE: A synthetic intermediate of pindolol, used for tachycardia, such as sinus tachycardia or paroxysmal tachycardia, extrasystol and hyperpiesia. This process is un- necessary for epichlorohydrin and the yield, purity of pindolol and synthetic operations are improved. n PREPARATION: 4-Hydroxyindole is converted into the alkali metal salt such as sodium metal or alkaline earth metal such as calcium salt in a solvent such as DMF or water. The salt is made to react with 3-chloro-1,2-propanediol to give 4-(2,3- dihydroxy-propoxy)indole. The product is made to react with ethylene carbonate to produce the titled compound of the formula. The titled compound is led to pindolol by reaction with an amine acid adduct, followed by reaction with isopropylamine. n COPYRIGHT: (C)1981,JPO&Japio |
| priorityDate | 1980-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.