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filingDate 1980-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00e05d41d1942ae4e7dbd49d4ba9ddae
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publicationDate 1981-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S56161369-A
titleOfInvention Novel vitamin d derivative
abstract NEW MATERIAL:25-Hydroxy-24-oxocholecalciferol of the formula. n USE: A medicine having a physiological activity like that of vitamin D. n PROCESS: 25-Hydroxyvitamin D 3 is incubated in a homogenate of a kidney obtained from a chicken of a domestic fowl to which vitamin D 3 is administered, and the resultant homogenate is subjected to a means, e.g. chromatography, to give the titled compound of the formula. 25-Hydroxyvitamin D 3 contains 1μg [26, 27- 3 H]- 25-hydroxyvitamin D 3 . The incubation is carried out in the gaseous phase of oxygen at 37°C for 30min, and the chromatography is the high speed liquid chromatography, e.g. Waters model 204 (manufactured by Waters Associates, Inc.).The compound of the formula is separated from the 25-hydroxyvitamin D 3 . n COPYRIGHT: (C)1981,JPO&Japio
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