http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S56135488-A

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06
filingDate 1980-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db86e55564a7a83dc416272fe23f1d38
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publicationDate 1981-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S56135488-A
titleOfInvention Novel preparative method of cephalosporanic acid derivative
abstract PURPOSE: A 7-aminocephalosporanic acid derivative is made to react with a novel active ester to safely produce the titled derivative used as an antibiotic agent against grampositive and -negative bacteria in high yield. n CONSTITUTION: The reaction between a 7-aminocephalosporanic acid derivative of formula I (R 1 is halogen, azide, benzimidazole) and 2-amino-1,3-thiazol-4-yl-acetic 1-dimethylaminoethyl-tetrazol-5-yl thiol ester is conducted, preferably at a molar ratio of 1:(1W2) in a solvent of DMF at 40W80°C to give the objective cephalosporanic acid derivative or its salt of formula III. The compound of formula II is novel and obtained, e.g., by reaction of 1-dimethylaminoethyl-tetrazole-5-thiol of formula IV with 2-amino-1,3-thiazol-4-ylacetic acid in a solvent at -50W+100°C. n COPYRIGHT: (C)1981,JPO&Japio
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priorityDate 1980-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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