| abstract |
NEW MATERIAL:A 7-substituted triazolopyrimidine derivative of formula I [R is group of CN, p-tolylsulfonyl, -COR 1 (R 1 is amino or substituted amino), etc.]. n EXAMPLE: 7-(p-Tolylsulfonyl)-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidine. n USE: An antitumor agent. n PROCESS: A triazolopyrimidine of formula II (X 1 is halogen) is reacted with an alkali cyanide or a salt of p-toluenesulfinic acid in a solvent, e.g. DMF, under cooling with ice to room temperature to give a compound of formula I a (R 4 is cyano or p- tolylsulfonyl). n COPYRIGHT: (C)1981,JPO&Japio |