| abstract |
NEW MATERIAL:A cyclohexenone derivative of formula I (R 1 is halogen; R 2 is lowr alkyl). n EXAMPLE: 4-Oxo-2-(4-chlorophenyl)-2-cyclohexen-1-ylacetic acid methyl ester. n USE: A synthetic intermediate of pharmaceuticals having antiphlogistic, analgesic and blood platelet coagulation inhibiting activities. n PROCESS: For example, the compound of formula II obtained by the reaction of dimethyl (4-chlorobenzoyl)ethyl amine with methyl iodide, is made to react with the dimethyl β-oxoadipate of formula III in the presence of an alkali to afford the compound of formula IV which is one of the compounds of formula IX. The compound of formula IX can be converted through the compound of formula V to the compound of formula VI which is the pharmaceutical referred above. n COPYRIGHT: (C)1981,JPO&Japio |