http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S56118099-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_630b360599ea5cf4b5bcbc0c6c0a3e2d |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00 |
filingDate | 1980-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecde6b5f9cc367bb380a5faf5ac789fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38670ef1339793e0feb67c054fca5682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c12d46ff4ba81db378332303379a958 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5e624ce4752b821c2e62b9a2eb0b93a |
publicationDate | 1981-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-S56118099-A |
titleOfInvention | Preparation of 7alpha-acylthio-4-en-3-oxosteroid |
abstract | PURPOSE: To prepare the titled compound useful as an antialdosteroic diuretic which is an extremely effective remedy, in high yield, by adding a thiocarboxylic acid to 4,6-diene-3-oxosteroid in a specific solvent. n CONSTITUTION: The titled compound is obtained by adding a thiocarboxylic acid (e.g. thioacetic acid) to a 4,6-diene-3-oxosteroid (e.g. 17-hydroxy-3-oxo-17α-pregna- 4,6-diene-21-carboxylic acid γ-lactone, etc.) in a solvent containing N-methyl-2- pyrrolidone or N,N-dimethylacetamide. The reaction may be carried out if necessary, in the presence of a catalytic amount of an acid stronger than the thiocarboxylic acid. n EFFECT: The production of by-product is essentially completely suppressed and the purification efficiency is improved, which result in remarkable economical effects. Stable even by reacting for a long time. n COPYRIGHT: (C)1981,JPO&Japio |
priorityDate | 1980-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.