| abstract |
PURPOSE: To obtain the titled compound useful as a hypoglycemic or cardiotonic in high yield, by protecting the amino group of 3,4-dimethoxyphenethylamine derivative as a raw material, followed by using. n CONSTITUTION: An α-halogenoacetophenone derivative shown by the formula II (X is halogen; R 1 is hydroxyl-protecting group to be eliminated by catalytic reduction) is condensed with a 3,4-dimethoxyphenethylamine derivative shown by the formula III (R 2 is amino-protecting group to be released by catalytic reduction), to give a compound shown by the formula IV. This compound is subjected to catalytic reduction, or it is partly reduced by a reducing agent to give a compound shown by the formula V temporarily and subjected to catalytic reduction, to prepare a benzyl alcohol derivative shown by the formula I. For example, α-(3,4-dimethoxyphenethylaminomethyl)-2-hydroxybenzyl alcohol having blood sugar reducing action is obtained. n COPYRIGHT: (C)1981,JPO&Japio |