| abstract |
PURPOSE: To obtain fibrinogen or its fractionated constituents 1 and 2 quantitatively, by bringing a fibrinogen-containing composition into contact with an amino carboxylic acid in the presence of an ionic strength adjustor in an aqueous medium. n CONSTITUTION: A fibrinogen-containing composition, e.g. blood plasma, is brought into contact with an amino-carboxylic acid, e.g. glycine, of the formla (n is a positive integer, preferably 1W3) in the presence of an inonic strength adjustor, e.g. sodium chloride, in an aqueous medium to isolate the fibrinogen or its constituents 1 or 2 separately in high purity. The quantitative isolation is useful for diseases induced from abnormal blood coagulation, e.g. hemorrhagic diseases, thrombosis, and D1C syndrome (intravascular coagulation syndrome) and diagnosis on liver diseases. n COPYRIGHT: (C)1980,JPO&Japio |