| abstract |
NEW MATERIAL:A 1-phthalazone derivative of formula I (R 1 , 2 are lower alkyl; R 3 is alkyl; R 4 is alkyl or phenyl; R 5 is alkyl, alkoxy, phenyl or pyridyl; R is H, phenyl, pyridyl, etc.). n EXAMPLE: The compound of formula II. n USE: An agent having thromboxan A 2 antagonistic activity, and useful for the prevention and remedy of arteriosclerosis, thrombosis, ischemic cerebral vascular lesion, and ischemic cardiopathy. n PROCESS: The compound I is prepared by reacting a compound III (e.g. 7-ethoxycarbonyl-6,8-dimethyl-4-formyl-1-phthalazone) with a compound IV [e.g. (methylsulfonyl)-acetone] in a solvent such as benzene, in the presence of a catalyst such as pyridine, at 50W150°C, esp. 80W120°C. n COPYRIGHT: (C)1980,JPO&Japio |