| abstract |
PURPOSE: A base having improved prolonged releasability of active constituents of medicines, etc., comprising a fatty acid glyceride, a specific organic substance, and an organic high polymer. n CONSTITUTION: A base comprising (A) a fatty acid glyceride melting at 37°C or above, (B) a water-soluble and low-viscosity organic substance, e.g. glycine, (C) an organic high polymer, e.g. sodium polyacrylate, swelling with water, and (D) a water-soluble surfactant, e.g. polyoxyethylene hardened castor oil derivative HCO- 60. The constituents (C) and (D) permit the swelling in Ringer's solution at a moderate rate, and disintegration. The base releases active constituents at a suitable freely controllable rate. n COPYRIGHT: (C)1980,JPO&Japio |