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filingDate 1978-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1980-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S557221-A
titleOfInvention Preparation of alethine derivative
abstract PURPOSE: To prepare an N-substituted alethine in high yield and purity, by reacting an N-substituted-β-alanine with cystamine or cysteamine in the presence of a deacidifying agent, a halogen compound, a tertiary phosphine or a tertiary phosphite. n CONSTITUTION: An N-substituted alethine is prepared by the direct condensation of an N-substituted-β-alanine with cystamine or cysteamine, or their salts, in the presence of a halogen compound such as halogen molecule, alkyl halide, etc., a tertiary phosphine such as triphenyl phosphine, or a tertiary phosphite. The N- substitution group is an amino-protecting group such as acyl group. The reaction is pref. carried out in an organic base as a solvent to remove the by-produced hydrogen halide from the system. n EFFECT: The objective compound can be obtained economically, by a simple process. n USE: Pharmacenticals or their intermediates. n COPYRIGHT: (C)1980,JPO&Japio
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