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filingDate 1978-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1980-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S5543012-A
titleOfInvention Novel anthracycline derivatine and its preparation
abstract NEW MATERIAL:1-HYDROXY-13-dihydro-daunomycin and N-formyl-1-hydroxy- 13- dihydrodaunomycin of formula I: (R is H or CHO group) and their acid addition salts. n USE: Carcinostatics. n PROCESS: ε-pyrromycinone or ε-isorhodomycinone of formula II (R is H or OH) is converted by strains of daunomycin-producing bacteria or their variation ones varied with ultraviolet light, e.g. Streptomyces coelureorubidus ME 130-A4 (FERM- P No.3540). particularly variation strains producing no pigment, e.g. Streptomyces coelureorubidus E-130-1u-222, to give the objective compound of formula I. n COPYRIGHT: (C)1980,JPO&Japio
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