| abstract |
PURPOSE: To prepare the title compound useful as an anti-phlogistic agent, easily, by reacting 2-thiophenaldehyde with a specific Gringnard complex of 2-(4-bromophenyl)-propionaldehyde acetal, and oxidizing and hydrolyzing the product. n CONSTITUTION: The objective compound IV is prepared by (1) reacting 2-thiophenaldehyde with a Grignard complex of 2-(4-bromophenyl)propionaldehyde acetal of formula I (R 1 , 2 are lower alkyl, or together form ethylene or propylene) in a solvent such as tetrahydrofuran, (2) oxidizing the resulting compound II pref. with chromium oxide to 2-[4-(2-thienylcarbonyl)phenyl]propionaldehyde acetal, (3) hydrolyzing the acetal, and (4) oxidizing the hydrolyzate with chromium oxide, etc. in the presence of an acid, e.g. sulfuric acid. n COPYRIGHT: (C)1980,JPO&Japio |