| abstract |
PURPOSE: An immunosuppressive agent useful for suppressing the rejection in implanting organs or the skin, or treating rheumatism, comprising N-(3,4-dimethoxy- phenyl)-L-glutamine as an active constituent. n CONSTITUTION: An agent comprising N-(3,4-dimethoxy phenyl)-L-glutamine of formula I as an active constituent, in a dose of 1W100mg/kg.day for parenteral administration, e.g. intramuscular injection, or 5W500mg/kg.day for oral administration, e.g. capsules or tablets, and useful as an anti-inflammatory drug. The compound of formula I is obtained by reacting N-phthalyl-L-glutamic acid anhydride of formula II with 3,4-dimethoxyaniline to form a compound of formula III, which is reacted with hydrazine hydrate. n COPYRIGHT: (C)1980,JPO&Japio |