| abstract |
PURPOSE: To obtain the title compound, a lenitive having no side effect, low toxicity and a high biological activity, by making use of the solubility difference of the diastereomeric mixture formed by treatment of a derivative of dl-benzazonine with an optically active organic acid in a solvent. n CONSTITUTION: A derivative of dl-benzazonine of the formula (R=H, methyl) is treated with an optically active organic acid (example; optically active mandelic acid, optically active tartaric acid, etc.) in a solvent to form diastereomeric mixture, form which a derivative of l-benzazonine is isolated by making use of the solubility difference of the isomers to a solvent, e.g. acetone, methyl ethyl ketone, methyl isobutyl ketone, etc. n COPYRIGHT: (C)1980,JPO&Japio |