| abstract |
NEW MATERIAL:α-[(α - Methyl - 2,3,4 - trimethoxy phenethylamino) methyl]-2- hydroxybenzyl alchol of formula I, or its pharmacologically acceptable acid addition salt. n USE: Medicines having improved hypoglycemic action. n PROCESS: A2-benzyloxy phenylglyoxal of formula II: (R is benzyl group) or its hydrate is condensed with α-methyl-2,3,4-trimethoxy phenethylamine of formula III to give an α-(α-methyl-2, 3, 4-trimethoxy phenethyl imino)-2-benzyloxy acetophenone of frmula IV, which is then reduced to form an α-[(α-methyl-2,3,4-trimethoxy phenethyl-amino) methyl]-2-benzyloxybenzyl alcohol of formula V. The compound of formula V is catalylically reduced to give the objective compound of formula I. n COPYRIGHT: (C)1980,JPO&Japio |