http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5524124-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| filingDate | 1978-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c01ebfde04f3050922528eb2d4777f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c41d81e0e5662d0afcd9a1975ec30252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54af6e8db59d6e04a3ed0c29582622ef |
| publicationDate | 1980-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5524124-A |
| titleOfInvention | 5-fluorouracil derivative and its preparation |
| abstract | NEW MATERIAL:A compound of formula I [R 1 and R 2 are H, -CH 2 SR 3 (R 3 is alkyl or aryl group which may be substituted), however, both R 1 and R 2 are not H]. n EXAMPLE: 1-Methylthiomethyl-5-fluorouracil. n USE: Carcinostatics effective against mouse leukemia L-1210. n PROCESS: 5-Fluoro-2,4-bis-trimethyl-silyloxypyrimidine is reacted with a chloride of the formula Cl-CH 2 SR 3 in the presence of an acid catalyst, e.g. SnCl 4 , iron chloride, TiCl 4 ,or AlCl 3 at room temperature to 120°C, e.g. 70°C for 1hr, to give the objective compound of formula I. n COPYRIGHT: (C)1980,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8910361-A1 |
| priorityDate | 1978-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.