| abstract |
NEW MATERIAL:2-Aceyl-6-aminomethylphenol derivatives of fomula I [R 1 is alkyl, H, C n H 2n -R 7 (n is 0, 1-6; R 7 is cycloalkl, phenyl, alkoxy, alkylthio);R 2 is alkyl, cycloalkyl, phenyl; R 3 , R 4 are H, R 2 along with R 3 or R 2 along with R 4 form alkylene; R 5 is H, alkyl; R 6 is H, alkyl, acyl]. n EXAMPLE: 2-Acetyl-4-tert.-butyl-6-aminomethylphenol. n USE: Anti-inflammatory agent; It is freed from the side effect of gastric ulcer and has anti-inflammatory, analgesic, antipyretic, diuretic and hypotensive activities, thus being effective on the treatment and prevention of diseases caused by inflammation, edema and hypertension. n PREPARATION: For example, A compound of formula II (R 10 is acyl) is subjected to the elimination reaction of the R 10 group to form the compound of formula I where R 6 is H. n COPYRIGHT: (C)1980,JPO&Japio |