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filingDate 1980-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1980-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S55162790-A
titleOfInvention Novel fortimicin compound and its preparation
abstract PURPOSE:A fortimicin compound of the formula (R1 and R2 are H or methylamino groups; R3 and R4 are H or methoxy groups; R2 and R4 are H and R3 is methoxy group when R1 is methylamino group; R1 and R3 are H and R4 is methoxy group when R2 is methylamino group), and its salt. EXAMPLE:Fortimicin AH. USE:An antimicrobial and an intermediate for the preparation of 4-N-fortimicins AH and AI useful as an antibiotic against sensitive Gram-positive and Gram-negative bacteria. PROCESS:A microorganism, e.g. Micromonospora olivoasterospora ATCC21819 (FERM-P No.1560), which belongs to the genus Micromonospora, and has the ability to produce fortimicins AH and AI, is incubated in a culture medium at 25- -40 deg.C and a neutral pH by the submerged spinner culture method to produce and accumulate antibiotic fortimicins AH and AI, which are isolated and recovered from the culture to give the compound of the formula.
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