| abstract |
NEW MATERIAL:A heterocyclic compound of formula I: (Het is nitrogen-containing five-or six-membered heterocyclic group; Z is S or O; R 1 is H, alkyl, cyano, carbamoyl group, etc.; Y is alkenyl, alkynyl, substituted amino group, etc.; m and n are integers 1W3), or its acid addition salt. n EXAMPLE: 3-(2-Pyridylmethylthio)-N-trichloroacetyl propionamidine hydrate. n USE: Suppressants for secretion of acid in the stomach, having the action without the anticholinergic action. The compound comprises a substance to suppress the secretion based on the histamine H 2 acceptor antagonism. n PROCESS: A compound of formula III is reacted with an amine of the formula H 2 NY to give the objective compound of formula I. n COPYRIGHT: (C)1980,JPO&Japio |