http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55151584-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfd617dc43a4c986d2dd81e4cb39d9dd |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1979-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5742f5321fbc613a9e91149331f6b7f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33f81cf3b74d1928e734a33e2ac50a73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_166c5bcc3053f8a20b55b1a164a1b50a |
| publicationDate | 1980-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S55151584-A |
| titleOfInvention | Preparation of 1,8-naphthyridine derivative |
| abstract | PURPOSE: To obtain the title compound useful as an intermediate for an antibacterial agent in high yields, by condensing a -4-hydroxy-7-methyl-1,8-naphthyridine-3- carboxylic acid derivative with chloral, followed by alkylation and reaction with an organic acid. n CONSTITUTION: A compound shown by the formula I (R 3 and R 6 are lower alkyl) is condensed with chloral in a polor solvent, e.g., acetic acid, DMF, etc. or without the solvent under heating from room temperatures to reflux temperatures to give a compound shown by the formula II, which is reacted with an alkylating agent, e.g., a halogenated alkyl, a dialkylsulfuric acid, etc. in the presence of a deoxidizer, e.g., KOH, etc. in a polar solvent, e.g., DMF, under heating to give a compound shown by the formula III. The compound shown by the formula III is heated in the presence of an organic strong acid, e.g., tosyl acid, etc. in acetic acid, acetic anhydidride, or their mixture at 50W140°C to prepare a compound shown by the formula IV. n COPYRIGHT: (C)1980,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9975892-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8551990-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008046135-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9133188-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9573945-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8614212-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8293737-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906912-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954231-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9023848-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233181-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017105818-A |
| priorityDate | 1979-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.