http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55139370-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_067cda10aaf6d4a5ca8180abe5a545c6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-10 |
| filingDate | 1979-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_815ac34e9e4115d0bcbf23a86f1b8c3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f01cfa7289bb968c35afd2dc09012ca1 |
| publicationDate | 1980-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S55139370-A |
| titleOfInvention | Preparation of 1,4-di-substituted piperazine |
| abstract | PURPOSE: To prepare the title compound useful as an antitussive, etc., in high yield, with a simple and economical process, by reacting 1-(2-phenyl-2-alkoxyethyl)-4- (halomethyl)-piperazine, etc. with a propiophenone derivative. n CONSTITUTION: The compound III is prepared by reacting a compound I (R is H, or alkyl; X ia halogen or OH) with a compound II (R 1 is H, halogen, alkyl or alkoxy), pref. in the presence of an organic solvent (e.g. alcohol, ether, aromatic hydrocarbon, etc.). The use of a reaction catalyst improves the yield of the compound III. The catalyst is either a basic catalyst (e.g. triethylamine) or a dehydration catalyst (e.g. dicyclohexylcarbodimide) depending upon whether the X of formula I is halogen or OH. The compound I is a novel compound, and can be prepared by reducing the reaction product of a compound IV and a halogenocarbonic acid alkyl ester. n COPYRIGHT: (C)1980,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H03227575-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0558271-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H05234473-A |
| priorityDate | 1979-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.