| abstract |
PURPOSE: A bone metabolism regulator capably of enhancing the ossification, comprising 1α-hydroxy-, and 24,25-dihydroxycholecalciferols. n CONSTITUTION: A bone metabolism regulator comprising (A) 1α-hydroxy-or 1,25- dihydroxycholecalciferol of formula I (R is H or OH) and (B) 24,25-dihydroxycholecalciferol of formula II in pharmacologically effective amounts. The active vitamin D 3 of formula I enhances the calcium absorption by the intestinal tract, and shows the ossification effect by its action with (B) and parathormone in the bone tissue in vivo. n USE: Rickets, renal osteodystrophy, osteoporosis, Behset's diseases, etc. n COPYRIGHT: (C)1980,JPO&Japio |