http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55133384-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01c1e0bc0628f76dea731cda5a666ca1 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 |
filingDate | 1979-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a7d3979e29bc356efe90e03ff06edd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c6769f8defd4fc938e1522235776f29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65a39cd8425e6990e8aab9d9041cc911 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14b55b8f14d47fab45504f95b06c9b89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae3aa0ff7524c041811da4f6b8c30127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41d3a10e23c077ef2dc703175bbf1ba4 |
publicationDate | 1980-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-S55133384-A |
titleOfInvention | Preparation of rifamycin derivative |
abstract | PURPOSE: To obtain the title compound useful as an intermediate for the synthesis of an antitubercular rifampicin readily in high yield, by reacting rifamycin S or SV with tert-butylazomethin in the presence of an oxidizing agent in chloroform. n CONSTITUTION: Rifamycin S or SV is reacted with tert-butylazomethin in the presence of an oxidizing agent, e.g. MnO 2 or PbO 2 , in chloroform at room temperature to the boiling point of the solvent, preferably 50W60°C, to give the compound of the formula. tert-Butylazomethine is obtained by reacting equimolar amounts of formalin with tert-butylamine. n EFFECT: The use of chloroform provides the objective substance in high yield without requiring an excess amine which has been essential. The product after the reaction is readily rinsed without replacing the solvent with another one. n COPYRIGHT: (C)1980,JPO&Japio |
priorityDate | 1979-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.