| abstract |
NEW MATERIAL:A thiopronine derivative I (R 1 is 1W8C alkyl which may be substituted with hydroxyl, carboxyl, amino, phenyl, etc., or a group obtained by removing mercapto group from glutathione or thiamine; n is 1 or 2) and its salts. n EXAMPLE: N-(S-carboxymethyl-2-mercaptopropionyl)glycine. n USE: Liver trouble-inhibitors. Antirheumatics. Also effective for remedy of cataract. Long-acting type of thiopromine. Remarkably stable. Liberates thiopromine in living bodies. n PROCESS: The compound (n is 1) is prepared by reacting thiopronine II with a compound III (X is halogen). The compound (n is 2) is prepared by reacting the compound II with a compound IV (Y is X, NO, CN, phthalimide, etc.). n COPYRIGHT: (C)1980,JPO&Japio |