http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55111793-A

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filingDate 1979-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acdc4a72a05380a741497495bc831eec
publicationDate 1980-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S55111793-A
titleOfInvention Production of coenzyme q10
abstract PURPOSE: To enable the production of coenzyme Q 10 on a large scale economically and stably, by a method wherein a specified coenzyme Q 10 -producing strain is cultivated to obtain cells and the coenzyme Q 10 is separated and extracted from the cells. n CONSTITUTION: A coenzyme Q 10 of formula I producing strain of Agrobacterium genus, Flavobacterium genus, Priozobium genus or Thiobacillus genus is cultivated to obtain cultivated liquid. Cell separation from the cultivated eiquid is carried out by a solid-liquid separation method, and then the coenzyme Q 10 is separated and extracted by a conventional method. The cultivation is carried out at a temp of 20W45°C and at a pH of 5W10 by either batchwise or continuous operation. The separation and extraction of the coenzyme Q 10 from the cells is carried out, e.g. by suspending the cells in ethanol, heating the suspension to 50W90°C for one hour or more and extracting the coenzyme. The crude extract can be purified by using alumina, silica gel, or the like. n COPYRIGHT: (C)1980,JPO&Japio
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