http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55111470-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01156aa8ec92c4b855de0734b6b32407 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D225-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1979-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bff6d3207f63b0b3f5765ea958fb19b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cf9d96bab23f219c0f12c7bdea2640c |
| publicationDate | 1980-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S55111470-A |
| titleOfInvention | Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient |
| abstract | NEW MATERIAL:A geldamycin derivative shown by formula I (R 1 is methoxy or di lower alkyl amino; R 2 is di lower alkyl amino). n EXAMPLE: 17-Dimethoxy-17,19-bisdimethylamino-geldanamycin. n USE: A synthetic intermediate for an antitumor agent, a drug for a veterinarian, or other derivative. a daily dose for an adult is 0.5W80mg/kg in the case of nonoral administration and 1W100mg/kg in the case of oral administration. n PROCESS: A geldanamycin shown by the formula II is reacted with a di lower alkylamine, e.g., dimethylamine, preferably in an organic solvent, e.g., a mixed solvent of chloroform and methanol at room temperature to give the desired compound shown by the formula I. The di lower alkylamine can also be used in the form of an aqueous solution. n COPYRIGHT: (C)1980,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7405208-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7378407-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7259156-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6872715-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6890917-B2 |
| priorityDate | 1979-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.