http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55105656-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f776ef10140e02fda39170d86551c0a5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 |
| filingDate | 1979-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef6cbe2b0e0e07c94b1a53e6e62f2519 |
| publicationDate | 1980-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S55105656-A |
| titleOfInvention | Preparation of n,n-disubstituted-o-(2,6-dichloroanilino) phenylacetamide |
| abstract | PURPOSE: To obtain the title compound useful as a raw material through an easy preparation of Diclofenac, a nonsteroid analgic antiphlogistica, by reacting N,N- disubstituted-O-bromophenylacetamide derivative with 2,6-dichloroaniline in the presence of a cupric catalyst. n CONSTITUTION: An N,N-disubstituted-O-bromophenylacetamide derivative shown by the formula I (R 1 and R 2 are lower alkyl; R 1 and R 2 link together with N and/or O to form a heterocyclic ring) is reacted with 2,6-dichloroaniline in the presence of a cupric catalyst, e.g., CuBr 2 [and, if necessary, an deoxidizer (e.g., an alkali metal carbonate, etc.] and a cocatalyst of NaI in a solvent, e.g., chlorobenzene at a temperature not lower than 80°C to give the title compound shown by the formula II. n EFFECT: The title compound is obtained from low-priced raw materials in extremely few steps in high yields in all processes and the procedures are simple. The compound is very safe and has a good crystallizability. n COPYRIGHT: (C)1980,JPO&Japio |
| priorityDate | 1979-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.