http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5498788-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e1d955a7b1560dc68cf7fd800e8fac |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-10 |
| filingDate | 1978-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41e640e427e838ec58eb131d5ff6bc9f |
| publicationDate | 1979-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5498788-A |
| titleOfInvention | Preparation of piperazine derivative and its acid addition salt |
| abstract | PURPOSE: To obtain a piperazine derivative and its acid addition salt having an antitussive action, e.g. Eprazinon, by reacting a piperazine derivative with a propiophenone derivative. n CONSTITUTION: A piperazine derivative of formula I: (R is lower alkyl group) is reacted with a propiophenone derivative of formula II: (A is tertiary amino group which may be removed easily in reaction with the compound of formula I) in the presence of an organic solvent, e.g. benzene or toluene, at a temperature around the boiling point for 3W20 hr to give a compound of formula III. The compound of formula I is obtained by reacting a 2-phenyl-2-alkoxyethyl bromide with anhydrous piperazine under heating and refluxing. n COPYRIGHT: (C)1979,JPO&Japio |
| priorityDate | 1978-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.