http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5488254-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_630b360599ea5cf4b5bcbc0c6c0a3e2d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1977-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c35086d659bed182865b1f5c9c2c4af4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5e624ce4752b821c2e62b9a2eb0b93a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38670ef1339793e0feb67c054fca5682 |
| publicationDate | 1979-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5488254-A |
| titleOfInvention | Production of 17-hydroxypregn-5-ene-20-ine-3-one |
| abstract | PURPOSE:Ethynylation of androst-4-ene-3,17-dione in the 17 position is effected by the reaction with a metal acetylide, then tha pH is controlled to produce title compound useful for synthesizing an intermediate of spironolactone, a diuretic, by simple operation in high yield. CONSTITUTION:The reaction of androst-4-ene-3,17-dione (abbreviated to 4AD) with a metal acetylide, in which the metal is preferably an alkali, in a molar ratio of 1 to 1-100, preferably 2-20, is conducted in a hydrophilic solvent as tetrahydrofuran or dioxane, at -50-50 deg.C to ethynylate selectively the carbonyl group in the 17 position of 4AD. Then a weak acid with a pK of lower than 2 as acetic, carbonic aicd, acidic salt of inorganic acid is added to the reaction mixture in an amount of 0.5-100 times the molar quantity of the base used in the ethynylation to make the pH 1-13, thus obtaining the objective compound. The ethynylation also can be effected using a strong base and acetylene. |
| priorityDate | 1977-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.