http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5476556-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2de3beee83d9c19278da409b72c777a8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1977-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_190f1d2173ee4d9de210cea79b9b662b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59b72f1da74dc80480bf5c440b9dc994 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34628049256aaab225a219993e040d6d |
| publicationDate | 1979-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5476556-A |
| titleOfInvention | Production of intermediate for prostaglandin analog |
| abstract | PURPOSE: The reaction of a specific prostanic acid derivative with a carboxylic acid is conducted in the presence of a phosphine compound and an azodicarboxylic dialkyl ester to produce with practical easiness title intermediate useful as a medicine. n CONSTITUTION: The reaction between a compound of formula I [X is ethylene, cis-vinylene; Y is ethylene, trans-vinylene; Z is trans-vinylene; R 1 is H, 1-12C alkyl; R 4 is single bond, 1-4C alkylene; R 5 is H, 1-8C alkyl; R 10 , R 11 are hydroxyl- protecting group where the case is excluded when Z is cis-vinylene and Z is trans- one] and a carboxylic acid of formula II (R 12 is 2-5C alkanoyl) is conducted in the presence of a phosphine compound of formula III (R 13 is 1-4C alkyl) and an azodicarboxylic dialkyl ester of formula IV (R 14 is 1-4C alkyl) to invert 15β-OH into 15α-OR 12 . Then the resulting compound of formula V is hydrolyzed in the presence of an alkali to produce the objective compound of formula VI. n COPYRIGHT: (C)1979,JPO&Japio |
| priorityDate | 1977-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6325 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419559542 |
Total number of triples: 18.