| abstract |
NEW MATERIAL:Cephalosporin derivative of formula I (R 1 is H, hydroxyl-substituted or non-substituted alkyl; R 2 is H, OH), and its salt. n EXAMPLE: 7-(D-alanyl-D-phenylglycyl)amino-3-(4-carbamoylpyridinium)methyl- Δ-cephem-4-carboxylate. n USE: Antibacterial agent effective to gram-positive and gram-negative bacteria, especially to Pseudomonas aeruginosa. n PROCESS: The compound IX is prepared by (1) reacting a phenylglycine derivative X with 7-aminocephalosporanic acid derivative III to afford a compound IV (2) eliminating the amino- and carboxyl-protecting groups from the compound IV, and (3) reacting with isonicotinic acid amide. n COPYRIGHT: (C)1979,JPO&Japio |