| abstract |
NEW MATERIAL:An acrylophenone derivative of formula I: (R is lower alkyl group). n EXAMPLE: 4'-Ethyl-2-methyl-acrylophenone. n USE: Intermediate forsynthesis of pharmaceuticals. For example, antispasmodics 4'-alkyl-2-methyl-3-piperidino-propiophenone can be obtained by reaction with pipenidine. n PROCESS: A methacrylic acid halide of formula II: ( X is halogen) is condensed with an alkylbenzene of formula III in the presence of a levis acid, e.g. aluminum chlorid, antimory pentachloride, etc. at a low temperature of -30W15°C by the Friedel-crofts reaction to give the objective compound of formula I. n COPYRIGHT: (C)1979,JPO&Japio |