http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S5461191-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_129e393582e6bdf4029baf2206522f45 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-08 |
| filingDate | 1977-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_381c4a5a9b840aeb37fca5cd71a023c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_154d5fc002b9989d3f7e15e08e45c30c |
| publicationDate | 1979-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S5461191-A |
| titleOfInvention | Preparation of 7beta-amino-3-methyl-3-cephem-4-carboxylic acids |
| abstract | PURPOSE: To prepare the title antibiotic in high yields easily, by ring closure of a readily available disulfide compound obtained from penicillin S-oxide with sodium nitride in one step. n CONSTITUTION: A disulfide compound of formula I: (R 1 is acyl group; R 2 is H or protective group of primary amino group bonded to R 1 : R 3 is ester residue; R 4 is organic residue) is treated with 0.01W10%, preferably 0.1W0.5% based on the weight of the disulfide compound of sodium nitride or hydrazoic acid in an aprotic polar solvent, e.g. dimethyl sulfoxide, hexamethyl phosphoric triamide to give the desired compounds of formula II. The reaction is at 0W80°C, preferably 5W40°C, for 1W5hr. The compound of formula I can be readily obtained from an S-oxide of penicillin G or V. n COPYRIGHT: (C)1979,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5336805-A |
| priorityDate | 1977-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.