| abstract |
PURPOSE: To obtain an asymmetric hydrogenation catalyst for org. cpds. each contg. prochiral C=C by coordinating a specific N-monosubstd. aminophosphine having a chiral substituent to Rh. n CONSTITUTION: An N-monosubstd. aminophosphine represented by general formula R×NHPR 2 ' (R×; a chiral substituent), e.g. 1,2-(R,R)-bis(diphenyl-phosphinamino cyclohexane is mixed with a Rh cpd. such as [Rh(1,5-hexadiene)Cl] 2 in solvent so that the amt. of the phosphine becomes twice as much as or in slightly excess of the amt. of the Rh cpd. Using the resulting asymmetric hydrogenation catalyst a cpd. having prochiral C=C, e.g. α-acylaminoacrylic acid is hydrogenated as usual to give a chiral cpd n COPYRIGHT: (C)1979,JPO&Japio |