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filingDate 1977-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_156db00e2d809bd00983d9dfed3f70f8
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publicationDate 1979-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S5452069-A
titleOfInvention Prostaglandin i2 analog compound and its preparation
abstract NEW MATERIAL:Prostaglandin I 2 analog compound I (Y is ethylene, trans- venylene; R 1 is H, 1-12C alkyl; R 2 is H, methyl, etc.; R 3 is single bond, 1-4C alkylene; R 4 is H, 1-8C alkyl, etc.; wary line is α,β,α+β-cordination; C 5 =C 5 is Z); their cyclodextrin-clathrate compound, and when R 1 is H, non-toxic salts of the acid. n EXAMPLE: (5Z,13E)-(9α,11α,15S)-6,9-eptithio-11,15-dihydroxyprosta-5,13-dienoic acid methyl ester. n USE: The compounds have arthery relaxing effect and esp. human blood platelet coagulation inhibiting effect, and useful as remedies for artheriosclerosis, cardiac infarction, thrombosis,etc. n PROCESS: The compound I is prepared by converting the C 9 -OH of a compound II (R 5 is H, 1-4C alkyl; R 7 is benzoyl, etc.) to alkylsulfonyl, reacting with a compound III (R 6 is 1-4C lakyl; Q is O, S), and further reacting under conditions. n COPYRIGHT: (C)1979,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S55500346-A
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Total number of triples: 29.