| abstract |
NEW MATERIAL:Prostaglandin analogs of formulaI[Y is trans-vinylene, ethylene; R 1 is H alkyl; R 2 is H, methyl, ethyl; R 3 is single bond, alkylene; R 4 is H, alkyl, cycloakyl, phenyl, phenoxy; is α-conformation, β-conformation, that is, S- and R-conformations or their mixture]or their clathrate with cyclodextrin or nontoxic salts when R 1 is H. n EXAMPLE: (13E)-(9α, 11α, 15S)-6-oxo-9-hydroxy-11,15-bis (tetrahydropyran-2-ylocy)- prosto-13-enioc methyl ester. n USE: Medicines for hypertension, disturbance of peripheral circulation, cardiac infarction, peptic ulcer and so on. n PREPARATION: OR 5 group of the compound of formulaII (R 5 is tetrapyrane-2-yl) is hydrolyzed to OH group, thus forming the objective compound of formulaI. n COPYRIGHT: (C)1979,JPO&Japio |