| abstract |
NEW MATERIAL:Compounds of formulaI(R 1 is lower alkanoyl; A is vinylene, ethylene, B is 1, 3-butadienylene, tetramethylene) and their salts. n EXAMPLE: 3-Deacetoxy-2, 3-didehydroleucomycin A 3 . n USE: Antibiotics. It has an antibiotic spectra against grampositive and negative bacteria similar to conventional macrolide antibiotics. Further it has no bitter taste and it can be orally dosed especially useful as syrup for infants. n PREPARATION: A conventional biotic such as leucomycin A 3 or gosamycin, of formula II (R 2 is acetyl, propionyl) is subjected to deacyloxylation on the 3-position in a hydrophilic organic solvent to afford said compound of formula III. n COPYRIGHT: (C)1979,JPO&Japio |