| abstract |
NEW MATERIAL:A compound of formula I. n USE: Antiesterase active substances having enlarged inhibitory enzyme groups compared with esterastin, a particularly powerful anticholesterol esterase activity, and expected possibility of application as a remedy for thrombosis and arteriosclerosis in addition to arthritis and rheumatic fever. n PROCESS: Esterastin of formula II dissolved in methanol is reduced with a hydrogenation catalyst, e.g. platinum oxide or Pd, in a hydrogen atmosphere or Paal's reduction apparatus for 2 hr to overnight. The catalyst is removed by filtration, and the filtrate is concentrated to give the objective compound of formula I. n COPYRIGHT: (C)1979,JPO&Japio |